Aldactone 100 is a potassium-sparing diuretic, which is caused by antagonism with aldosterone (a mineral corticosteroid hormone in the adrenal cortex). Aldosterone promotes the reabsorption of sodium ions in the renal tubules and enhances the excretion of potassium ions. Spironolactone is a competitive aldosterone antagonist on the effect of the distal nephron (competes for binding sites on cytoplasmic protein receptors, reduces the synthesis of permeases in the aldosterone-dependent portion of the collecting tubules and distal tubules), increases the excretion of sodium ions, chlorine and water and reduces the excretion of potassium ions and urea, reduces the acidity of urine. Increased diuresis causes an antihypertensive effect, which is not constant. The diuretic effect is manifested at 2-5 days of treatment.
Indications for use Aldactone 100:
- Edema in chronic heart failure, liver cirrhosis, and nephrotic syndrome.
- Edema in the II and III trimesters of pregnancy.
- Arterial hypertension, included with aldosterone-producing adrenal adenoma (as part of combination therapy).
- Primary hyper aldosteronism. Aldosterone-producing adrenal adenoma (long-term supportive therapy with contraindications to surgical treatment or in case of refusal from it). Diagnosis of hyper aldosteronism.
- Hypokalemia and its prevention in the treatment of saluretic.
- Polycystic ovary syndrome, premenstrual syndrome.
The dosage of Aldactone 100 is set individually, depending on the severity of violations of water-electrolyte metabolism and hormonal status. With edematous syndrome, 100–200 mg per day in 2–3 doses (usually in combination with a “loop” or thiazide diuretic) daily for 14–21 days. Dose adjustment should be carried out taking into account plasma potassium concentrations.